Shank2 gene in hcc

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August undefined, 2024

Webb7 apr. 2024 · Sasaki et al. demonstrate that epithelial Shank2 localizes at tight junctions (TJs) via its epithelia-specific N terminus and interacts with aPKC. Through small …

Shank2 - Wikidata

WebbBesides, RAB7A was a multi-pathway target involved in the malignant progression of HCC. Lipophagy-related gene RAB7A is involved in immune regulation and malignant progression in hepatocellular carcinoma Comput Biol Med. 2024 Apr 6;158:106862. doi: 10.1016/j.compbiomed.2024.106862. ... Webb7 maj 2024 · Although rare, chromothripsis, multiple structural rearrangements in single catastrophic mitosis, was also reported in HCC [ 5 ]. A broad range of cancer-related … the origins of the greeks

SHANK2 is a frequently amplified oncogene with evolutionarily conserved ...

WebbA pooled analysis of public gene expression datasets showed downregulation of SHANK2 in kidney cancer specimens, suggesting that this gene might play an important role … WebbSHANK2 is part of cluster 88 Choroid plexus - Transmembrane transport with confidence i Confidence is the fraction of times a gene was assigned to the cluster in repeated … Webb14 juni 2012 · Shank2 (also known as ProSAP1) is a multi-domain scaffolding protein and signalling adaptor enriched at excitatory neuronal synapses, and mutations in the human SHANK2 gene have recently been... the origins of the modern world 4th edition

Bioinformatics analysis revealed hub genes and pathways …

Mutations in SHANK2 have been associated with autism spectrum disorder (ASD) and schizophrenia. In particular, heterozygous loss-of-function mutations have a near-complete penetrance in ASD. Neurons generated from people with ASD and SHANK2 mutations develop larger dendritic trees and more synaptic connections than those from healthy controls. In addition, common mutations in SHANK2 have been linked to bipolar disorder. WebbMethods. Patients with a diagnosis of malignant neoplasm in the head and neck (HN) region and who had serology performed for HCV were included. Patients were classified … the origins of the english novelWebb1 dec. 2024 · We identified 5 genes ( WNK2, RUNX1T1, CTNNB1, TSC1, and TP53) harboring somatic mutations that correlated with early tumor recurrence after curative … the origins of the last name jones

"Webb21 okt. 2015 · Human PanNET core clinical gene expression dataset.} \description{This is a gene expression dataset for human PanNET samples to be merged with mouse gene … " - Shank2 gene in hcc

Shank2 gene in hcc

Shank mutant mice as an animal model of autism Philosophical ...

WebbGenetic CategoryRare Single Gene Mutation, Syndromic, Genetic Association, Functional. Rare SHANK2 deletions have been identified in ASD cases, but not in controls (PMIDs … WebbLeblond et al, 2014 performed a meta-analysis of the SHANK gene (SHANK1, SHANK2, SHANK3) copy number and coding sequencing variants in patients with ASD in order to …

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Webbprotein-coding gene in the species Homo sapiens. This page was last edited on 20 January 2024, at 07:33. All structured data from the main, Property, Lexeme, and EntitySchema … WebbSHANK family proteins (SHANK1, SHANK2, & SHANK3) have emerged as promising candidates for modeling ASD in mice due to strong genetic evidence showing …

Webb7 apr. 2024 · Focal gains on 11q13.3 in 37% of cases (19/51), consistently involved CTTN and SHANK2 genes. Twelve of these cases (23,5%), had a broader region of gain that also included the CCND1, FGF19, FGF4 and FGF3 genes. SHANK2 and CTTN are co-amplified in several cancers, these proteins interact functionally together and are involved in cell … Webb30 sep. 2024 · This study suggests that SHANK2 rs10792565 is associated with an increased risk of RCC and that SHANK2 may play a role in RCC progression. The …

Webb8 juli 2024 · DYNLL2, H2AFJ, SHANK2, ZWILCH, CDC14A, IFT20, MTA3, SERPINA1 and TCF4 were confirmed as key genes in this process. Moreover, our study showed Akt … WebbThe .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

WebbThe SHANK2 gene, located on the 11th chromosome, provides the code for producing SHANK2 protein which is essential for proper brain function. SHANK2 protein plays an …

Webb21 mars 2024 · SHANK2 (SH3 And Multiple Ankyrin Repeat Domains 2) is a Protein Coding gene. Diseases associated with SHANK2 include Autism 17 and Autism Spectrum … the origins of the liberation struggleWebbSHANK3 overexpression is caused by duplications of the SHANK3 gene. The symptoms of SHANK3 overexpression include hyperkinetic disorders and seizures. The roles played … the origins of the mestizo cultureWebbSH3 and multiple ankyrin repeat domains (SHANK) is a family of scaffold proteins that were first identified to be involved in balancing synaptic transmission via regulation of … the origins of the movementWebb27 mars 2024 · The expression of the model genes was correlated with immune cell infiltration, angiogenesis-related genes, and sensitivity to antiangiogenic therapy (P<0.05). Discussion: In conclusion, we established a prognostic signature of 24 genes based on pyroptosis clusters for HCC patients, providing insight into the risk stratification of HCC. the origins of the middle class cultureWebb25 mars 2024 · The transcriptome in isogenic SHANK2 neurons was perturbed in synapse, plasticity, and neuronal morphogenesis gene sets and ASD gene modules, and activity … the origins of the internet summaryWebb27 juni 2012 · By genomewide microarray scan for copy number variants (CNV) in a German cohort of 184 unrelated individuals with mental retardation and a series of 396 … the origins of the mithraic mysteriesWebb13 juli 2024 · Interestingly, a mammalian homolog of Prosap, SHANK2, is the most frequently amplified gene on 11q13, a major tumor amplicon in human cancer. Gene … the origins of the names of the 12 months