Plekhm2 salmonella

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August undefined, 2024

WebPLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining … WebDec 1, 2016 · Another Salmonella effector, SifA, engages SKIP and kinesin-1 to pinch off vesicles from the Salmonella vacuole and move them in anterograde direction (Dumont et al., 2010). SifA also forms a complex with SKIP and Rab9A, preventing transport of mannose 6-phosphate receptors (MPRs) from endosomes to the TGN and thus causing …

Mechanisms and functions of lysosome positioning

WebCDC estimates Salmonella bacteria cause about 1.35 million infections, 26,500 hospitalizations, and 420 deaths in the United States every year. Food is the source for most of these illnesses. Most people who get ill from Salmonella have diarrhea, fever, and stomach cramps. WebNov 16, 2012 · Salmonella enterica is an intracellular bacterial pathogen that replicates within membrane-bound vacuoles through the action of effector proteins translocated into host cells.Salmonella vacuoles have characteristics of lysosomes but are reduced in hydrolytic enzymes transported by mannose-6-phosphate receptors (MPRs). We found … brown\\u0027s small engine repair rapid city

Salmonella infection (salmonellosis) - Queensland Health

WebSalmonella infection (salmonellosis) is a bowel infection caused by salmonella bacteria. It usually gets better by itself within a week, but some people need to take antibiotics. Some people can become very unwell with dehydration. You can catch salmonella from eating infected animal products or from contact with animals or sick people. WebWhat is Salmonellosis? Salmonellosis is a bacterial infection caused by Salmonella bacteria, which have 2 species, S. enterica and S. bongori and over 2400 ... evga turn off rgb

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WebDec 20, 2015 · The PLEKHM2 cDNA2156_2157delAG variant causes the frameshift p.Lys645AlafsTer12 and/or the skipping of exon 11 that results in deletion of 30 highly … WebPLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining differential gene expression in human hematopoietic stem cells has shown it to be specifically expressed in stem cells, suggesting that PLEKHM2 may play a role in … brown\u0027s small engine repair culpeperWebDec 10, 2014 · To form this replicative niche, Salmonella targets the Rab7 GTPase to recruit host membranes through largely unknown mechanisms. We show that Pleckstrin homology domain-containing protein family ... brown\u0027s smash repairs

"WebNormalized expression data for each known or novel expressed feature of 'PLEKHM2' The following table summarizes the expression values of all known features of the gene ' PLEKHM2 ' in each library. Known features (i.e. those that correspond to one or more EnsEMBL transcripts) are included regardless of their expression level. " - Plekhm2 salmonella

Plekhm2 salmonella

PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING PROTEIN, …

WebMar 21, 2024 · PLEKHM1 and PLEKHM2 compete for interaction with ARL8B (PubMed:28325809). ... In case of infection contributes to Salmonella typhimurium pathogenesis by supporting the integrity of the Salmonella-containing vacuole (SCV) probably in concert with the HOPS complex and Rab7. WebNov 16, 2012 · Salmonella vacuoles have characteristics of lysosomes but are reduced in hydrolytic enzymes transported by mannose-6-phosphate receptors (MPRs). We found …

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WebPleckstrin homology domain-containing family M member 2 is a protein that in humans is encoded by the PLEKHM2 gene.[5] For faster navigation, this Iframe is preloading the Wikiwand page for PLEKHM2 . WebIt binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the …

WebSalmonella infection: Abnormal: Citrobacter infection: Normal: All tests and analysis from: Model organisms have been used in the study of PLEKHM2 function. A conditional knockout mouse line, called Plekhm2 tm1a(EUCOMM)Wtsi was ... WebIt binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the …

WebJul 21, 2016 · Salmonella enterica is an intracellular bacterial pathogen that replicates within membrane-bound vacuoles through the action of effector proteins translocated into host … WebIt binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the …

WebOther studies have shown that PLEKHM2 is required for interaction with the Salmonella virulence factor SifA for Salmonella pathogenesis, suggesting that PLEKHM2 has cellular roles other than in the developing embryo. Application Note. Anti-PLEKHM2 Antibody has been tested for use in ELISA, Western Blotting, Immunohistochemistry and ...

WebTarget Information. PLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a … brown\u0027s small engine repair troy ncWebPLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining differential gene expression in human hematopoietic stem cells has shown it to be specifically expressed in stem cells, suggesting that PLEKHM2 may play a role in … brown\u0027s social clubhttp://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human&hgg_chrom=none&hgg_type=knownGene&hgg_gene=uc010obo.2 brown\u0027s smokehouse meats