P-stathmin
WebSep 10, 2024 · Stathmin is a downstream protein of KIAA1199-PP2A complex Stathmin, a major microtubule-destabilizing phosphoprotein, is reported to be overexpressed in different human malignancies, and its... WebApr 12, 2024 · STATHMIN-2 has been shown to be highly expressed in human motor neurons, the cells that primarily degenerate in ALS. ANQUR, a multi-center, randomized, double-blind, placebo-controlled multiple ascending dose study, is the first to assess a therapy that rescues STMN2 expression in patients with ALS.
P-stathmin
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WebOp18/stathmin is a 17-kDa protein that has been recently revealed to bind tubulin and destabilize microtubules ( 19 ) and is negatively regulated by phosphorylation by a variety … WebSep 9, 1997 · Stathmin is an important regulatory protein thought to control the dynamics of microtubules through the cell cycle in a phosphorylation-dependent manner. Here we …
WebJan 13, 2024 · The protein expression of p-stathmin (Ser63) showed the same trend in the mPFC. The protein and mRNA expression of β-tubulin and MAP-1B was consistent with that of p-stathmin; it reached a peak on the 7th day, and then decreased in the rat hippocampus, mPFC, and amygdala. Stathmin in the memory loop, especially in the hippocampus, … WebDec 8, 2024 · Stathmin 1 activity is reduced during mitosis (as demonstrate by increased p-Stathmin 1 S16) and increases post-mitosis (reduced p-Stathmin 1 S16), indicating that this protein participates in microtubule dynamics and cell cycle progression in PML-RARα cells. Paclitaxel was an efficient pharmacological agent in inducing microtubule ...
Stathmin is a ubiquitous phosphorylated protein which makes it act as an intracellular relay for diverse regulatory pathways, functioning through a variety of second messengers. Its phosphorylation and gene expression are regulated throughout development [11] and in response to extracellular … See more Stathmin, also known as metablastin and oncoprotein 18 is a protein that in humans is encoded by the STMN1 gene. Stathmin is a highly conserved 17 kDa protein that is crucial for the regulation of the cell See more Stathmin, and the related proteins SCG10 and XB3, contain a N-terminal domain (XB3 contains an additional N-terminal hydrophobic region), … See more Stathmin interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex. One mole of stathmin binds to two moles of tubulin dimers through the stathmin-like domain (SLD). When stathmin sequesters tubulin into the T2S … See more Mice without stathmin have deficiency in innate and learned fear. Stathmin−/− females do not assess threats well, leading to lack of … See more The function of Stathmin is to regulate the cytoskeleton of the cell. The cytoskeleton is made up of long hollow cylinders named microtubules. These microtubules are made up of alpha and beta tubulin heterodimers. The changes in cytoskeleton are … See more Stathmin's role in regulation of the cell cycle causes it to be an oncoprotein named oncoprotein 18 (op18). Stathmin (aka op18) can cause uncontrolled cell proliferation when mutated and not functioning properly. If stathmin is unable to bind to tubulin, it … See more • Sobel A (August 1991). "Stathmin: a relay phosphoprotein for multiple signal transduction?". Trends in Biochemical Sciences. 16 (8): … See more Web您好！欢迎来到炼石商城 请登录 注册 我的订单; 我的炼石
WebRabbit IgG was used as a negative control. b Western blotting analysis of KIAA1199, stathmin and phosphorylated stathmin (p-Stathmin, Ser16) in HCT116 cell transfected with indicated constructs. c ...
WebFeb 22, 2010 · Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy† Human Molecular Genetics Oxford Academic Abstract. Spinal muscular atrophy (SMA), a motor neuron degeneration disorder, is caused by either mutations or deletions of survival motor neuron 1 (SMN1) gene find current chipset driver versionWebJan 17, 2024 · Non-small cell lung cancer (NSCLC) is among the leading causes of human mortality. One reason for high rates of NSCLC mortality is that drug resistance is a major problem for both conventional chemotherapies and less-toxic targeted therapies. Thus, novel mechanistic insights into disease pathogenesis may benefit the development of … gtownradio.comWebStathmin has a long α-helix that binds laterally to a pair of tubulin dimers, blocking their polymerization. This sequestration of dimers may promote catastrophes. Thus, … gtownroses bellsouth.net