WebApr 5, 2024 · There are 4 ways to get from Charleston to Myrtle Beach by bus, train, night bus or car Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner. Recommended Bus Take the bus from Charleston Amtrak Station to Columbia Take the bus from Columbia to Myrtle Beach, … WebA Scenic Drive From North Get off I-64 at Hampton, Va. Go South on I-664 through Monitor-Merrimack Memorial Bridge-Tunnel. Take I-64 toward Norfolk/Virginia Beach; then go south on US-17 at Deep Creek, Va. to South Mills, NC. Follow NC-343 south to US-158 South to The Outer Banks. From The West Via I-95 or I-85 into North Carolina.
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