Ctcf zinc fingers
WebBACKGROUND: CTCF (CCCTC-binding factor) is an evolutionarily conserved zinc finger protein involved in diverse functions ranging from negative regulation of MYC, to chromatin insulation of the ... WebDec 8, 2024 · Ctcfl CCCTC-binding factor (zinc finger protein)-like [ (house mouse)] Gene ID: 664799, updated on 8-Dec-2024. Summary. Enables histone binding activity and …
Ctcf zinc fingers
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WebApr 15, 2016 · The role of the zinc finger protein CTCF in organizing the genome within the nucleus is now well established. Widely separated sites on DNA, occupied by both CTCF and the cohesin complex, make physical contacts that create large loop domains. Additional contacts between loci within those domains, often also mediated by CTCF, tend to be … WebCTCF is a multivalent transcription factor and uses different combinations of zinc fingers (ZFs) to bind diverse target sequences . Tumor-derived point mutations in ZF3 and ZF7 did not totally abrogate the DNA-binding ability of CTCF; instead, they selectively blocked binding to some CTCF target sites, but not to others ( 25 ).
WebThese results demonstrate that CTCF activates transcription from the APP promoter and that the activation domain is located on the N-terminal side of the zinc finger domain . A … WebMay 11, 2024 · Ubiquitously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is normally only present in the testis. However, it is also aberrantly expressed in many cancers. While it is known that shared and unique zinc finger sequences in CTCF and CTCFL …
WebJun 26, 2009 · CTCF is a highly conserved zinc finger protein implicated in diverse regulatory functions, including transcriptional activation/repression, insulation, imprinting, and X chromosome inactivation. Here we re-evaluate data supporting these roles in the context of mechanistic insights provided by recent genome-wide studies and highlight … WebThe CTCF protein The organization of the chicken and human CTCF loci is shown in Fig. 1a,b. The exon–intron organization is identical in mice and humans, as are the sequences of the entire promoter regions, 5 ′- and 3′-untranslated regions (UTRs) and each splice donor–acceptor site(G.N. Filipova et al., unpublished). Compared with the ...
WebMar 19, 2024 · transcriptional repressor CTCF Names 11-zinc finger protein CTCFL paralog. NCBI Reference Sequences (RefSeq) Go to the top of the page Help. NEW Try …
WebJul 29, 2024 · The 11 zinc finger (ZF) protein CTCF regulates topologically associating domain formation and transcription through selective binding to thousands of genomic sites. Here, we replaced endogenous ... churn valley railwayWebThe 11 zinc fingers (ZFs) of the transcription factor CTCF play a versatile role in the regulation of gene expression. CTCF binds to numerous genomic sites to form chromatin … dfmea severity scoringWebOct 27, 2024 · Thus, ZF8 connects CTCF zinc fingers that recognize modules 1-2 and functions as a bridge to span the gap between modules 1 and 2 (Supplementary information, Figure S4). In contrast to ZFs 3-7 and ... dfmea to pfmeaWebJan 28, 2024 · Furthermore, CTCF-BORIS chimeric constructs provided evidence that, besides the N terminus of CTCF, the first two CTCF zinc fingers, and likely the 3D geometry of CTCF-DNA complexes, are also involved in cohesin retention. Based on this knowledge, we were able to convert BORIS into CTCF with respect to cohesin … churn vertalingWebCCCTC-binding factor (CTCF) is a zinc-finger protein, serving an important part in the genome architecture as well as some biochemical processes. Over 70,000 CTCF binding … dfm entity searchWebOct 16, 2024 · Our data confirm that a spectrum of loss-, change- and gain-of-function impacts on CTCF zinc fingers are observed in cell growth regulation and gene … dfmff30 hotmail.comchurn verb meaning