Cisplatin induced hypocalcemia

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August undefined, 2024

Webmannitol, or furosemide-induced diuresis is used t o effectively decrease cisplatin-induced nephrotoxicity. 7. Lower doses of cisplatin are given with less intensive hydration. For example, patients receiving doses of 35 mg/m. 2 . ... hypocalcemia may become symptomatic, with muscle irritability or cramps, clonus, tremor, carpopedal spasm and ... WebSep 4, 2009 · It should be noted that cisplatin causes hypocalcemia in a dose-dependent manner. Indeed, hypocalcemia is a frequent adverse effect of high-dose cisplatin …

Cisplatin-induced hypomagnesemia with seizures: a case report …

WebJan 12, 2024 · Hypomagnesemia is often associated with hypokalemia (due to urinary potassium wasting) and hypocalcemia (due both to lower parathyroid hormone secretion and end-organ resistance to its effect). (See "Hypomagnesemia: Clinical manifestations of magnesium depletion" .) The major causes of hypomagnesemia will be reviewed in this … WebMar 22, 2024 · They exert their main toxic effect within the tubular cell by altering phospholipid metabolism. In addition to their direct effect on cells, aminoglycosides cause renal vasoconstriction. The 2... diabetes self efficacy tool

DRUG NAME: Cisplatin - BC Cancer

WebNational Center for Biotechnology Information WebApr 10, 2024 · Med-Surg Nursing. Hypocalcemia is when there are low levels of calcium in the blood. Calcium is an electrolyte that plays a vital role in many bodily functions, including muscle contraction, nerve transmission, and bone formation. Various factors, including nutritional deficiencies, medications, and underlying medical conditions, can all lead ... WebHypomagnesemia is a common side effect of cisplatin occurring . in 90% of patients by the fourth cycle of treatment caused by renal tubular damage leading to increased renal … diabetes seat belt cover

Electrolyte Disorders Induced by Antineoplastic Drugs - Frontiers

Cisplatin-induced hypocalcemia and hypomagnesemia - PubMed

WebMar 8, 2024 · Hypocalcemia may be associated with a spectrum of clinical manifestations, ranging from few (if any) symptoms if the hypocalcemia is mild and/or chronic to … WebApr 12, 2024 · In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic … cindy crawford lip sync battleWebJan 12, 2024 · There are two major mechanisms by which hypomagnesemia can be induced: gastrointestinal or renal losses . Regardless of the cause, hypomagnesemia … diabetes self management algorithm of care

"WebJul 8, 2010 · Cisplatin based therapy for the treatment of solid organ tumors is commonly associated with several renal abnormalities including; *hypokalemia * hypomagnesemia *hypocalcemia *hypophosphatemia *fanconi-like syndrome * acute kidney injury We have all seen these complications on the renal consult service at least once. " - Cisplatin induced hypocalcemia

Cisplatin induced hypocalcemia

Cisplatin induced hypomagnesemic hypocalcemia: a …

WebCisplatin is a common cause of hypomagnesemia and hypokalemia due to renal magnesium (Mg) and potassium (K) losses. Magnesium plays an important role in the maintenance of intracellular K. An unrecognized and untreated Mg depletion can lead to a refractory K repletion.

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WebJul 24, 2024 · Cisplatin, a chemotherapeutic drug, can also cause hypocalcemia through hypomagnesemia. Foscarnet can cause hypocalcemia by forming complexes with ionized calcium, thereby reducing levels of ionized calcium. It is therefore important to regularly monitor calcium levels during treatment with all of the above-mentioned drugs. [8] [9] http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf

WebMar 9, 2024 · Cisplatin is a clinically advanced and highly effective anticancer drug that is used for the treatment of various solid tumors, such as lung cancer, stomach cancer, and ovarian cancer [1]. However, nephrotoxicity is the … WebApr 5, 2024 · causes of hypocalcemia Severe inflammation (sepsis, major burns). Pancreatitis (especially: hypertriglyceridemic pancreatitis). Citrate (massive transfusion, plasmapheresis, leukapheresis, renal replacement therapy). Ethylene glycol poisoning. Alkalosis: Respiratory alkalosis (e.g., panic-induced).

WebMar 3, 2024 · Hypokalemia occurred more frequently than hypocalcemia in cisplatin group. Electrolyte abnormalities were less common with carboplatin and oxaliplatin. Our study indicated that hypomagnesemia occurs sequentially and commonly with platinum based chemotherapy despite corrective measures. WebJul 24, 2024 · Cisplatin, a chemotherapeutic drug, can also cause hypocalcemia through hypomagnesemia. Foscarnet can cause …

WebMay 10, 2006 · Hypomagnaesemic induced hypocalcaemia is caused by inhibition of parathyroid hormone secretion, impaired calcium release from the bones and low tissue responses to PTH due to low magnesium levels. Cisplatin associated hypocalcaemia and hypercalciuria can not be influenced by calcium supplementation.

WebThese effects are due to renal tubular damage. Cisplatin greatly increases the urinary excretion of magnesium and calcium; increased excretion of potassium, zinc, copper and … diabetes self foot examWebJul 18, 2024 · Cisplatin may cause hypomagnesemia by downregulating the TRPM6/EGF pathway. Of note, Mg co‐administration mitigates both cisplatin‐induced … cindy crawford loveseat sleeperWebApr 15, 2024 · Neurologically, very severe hypophosphatemia (<0.6 mg/dL) can contribute to paresthesia, altered mental status, encephalopathy, seizures and coma [ 14 ]. Depletion of ATP in the heart can result in depression of myocardial performance and tachyarrhythmias in patients with serum phosphate ˂1.5 mg/dL [ 15 ]. diabetes self-management education curriculumWebHypocalcemia is uncommon and has been attributed to hypomagnesemia resulting from use of a chemotherapeutic regimen. Very few publications have described … diabetes self-management trainingWebMar 17, 2016 · It is likely that cisplatin contributed to the profound hypocalcemia in this patient, who presented with a serum Mg of 0.7 mg/dL. Denosumab, a monoclonal … diabetes self management magazine accountWebCisplatin-induced hypomagnesemia with seizures: a case report and review of the literature Gynecol Oncol. 1988 May;30(1):104-13. doi: 10.1016/0090-8258(88)90052-2. Authors S L Bellin 1 ... Hypocalcemia / chemically induced Hypokalemia / … diabetes self management education standardsWebJul 19, 2024 · Usually, the hypocalcemia is resistant to calcium or vitamin D therapy. Normocalcemia and relief of clinical symptoms can be attained by administration of high oral doses of magnesium, up to 20 times the normal intake. ... Cisplatin- and amphotericin B–induced magnesium deficiency is associated with hypocalciuria, which suggests … cindy crawford luggage